Book Chapter
Understanding the nature of prion diseases using cell-free assays.
VA Lawson
Methods in Molecular Biology | Published : 2008
Abstract
A central event in the transmission and pathogenesis of transmissible spongiform encephalopathy diseases is the misfolding of the prion protein. Considerable progress has been made in our understanding of this misfolding event through the development of cell-free assays that mimic the molecular features of prion propagation. This chapter reviews the contribution of cell-free assays to our understanding of prion propagation.